At Beauty by Doctor (BBD), we incorporate evidence-based approaches to skin management. Our medical director, Dr Phoebe Jones, oversees the use of specifically compounded Sirolimus cream for patients where clinically indicated to address changes in skin characteristics.

Important information
Prescription-only medications are not suitable for self-selection and should only be used under the direction of a qualified medical practitioner. A consultation is required before any prescription treatment can be recommended or prescribed.

How Sirolimus Functions in Skin Treatment
Sirolimus works by inhibiting the mTOR (mammalian target of rapamycin) pathway, a cellular signalling pathway involved in various processes, including growth, proliferation, and protein synthesis.
Research suggests that inhibiting the mTOR pathway may influence several physiological factors related to skin quality:
Support for cellular health: Sirolimus may assist in managing the presence of senescent cells, which are associated with changes in skin quality over time.
Support for structural proteins: Studies have indicated that Sirolimus can play a role in collagen synthesis, which may assist in managing skin elasticity and the appearance of fine lines.
Maintenance of skin barrier function: Sirolimus may assist in supporting the skin's natural barrier, which can influence hydration levels and responses to environmental factors.
A study published in the Journal of Clinical and Aesthetic Dermatology observed that topical Sirolimus was associated with changes in skin texture and the appearance of fine lines after 12 weeks of use. Another study published in the Journal of Drugs in Dermatology reported findings related to skin elasticity and hydration.
Dr Phoebe prescribes a custom-compounded Sirolimus 0.2% cream for patients when appropriate, focusing on the management of skin texture and tone. This cream is formulated to deliver the active ingredient based on individual clinical requirements.
It is important to note that Sirolimus cream is a prescription-only medication. It is only prescribed if a BBD physician deems it suitable for an individual after a thorough consultation and evaluation of their medical history and specific skin concerns.

Is Sirolimus Cream Suitable for You?
Sirolimus cream may be a suitable option for individuals seeking to address skin texture, fine lines, and overall skin characteristics through a topical medical approach. A consultation with a qualified physician is required to determine if this treatment is appropriate for your clinical needs.

Suitability for treatment is determined during consultation. All medical and cosmetic procedures carry risks, and outcomes vary between individuals. While complications are uncommon, it is important that potential risks, including rare adverse events, are understood. For more information, please refer to our Treatment Complications page: https://beautybydoctor.com/pages/concerns/treatment-complications