Rejuran: A Deep Dive into the Science Behind Polynucleotide Therapy

Rejuran is a polynucleotide-based treatment developed in South Korea. It uses polynucleotide (PN) derived from salmon testicular tissue and is utilised in aesthetic medicine to support skin quality through cellular-level processes. At Beauty by Doctor in Bondi Junction, Sydney, Rejuran treatments are tailored based on individual assessment and treatment goals.

The Origins of Rejuran: A Korean Development
Rejuran originated in South Korea and was initially introduced in a medical context for wound healing applications. The term “salmon sperm facial” is commonly used but not scientifically accurate, as the active ingredient is derived from salmon testicular tissue rather than sperm.
Over time, polynucleotide formulations have been incorporated into aesthetic treatments due to their interaction with skin structure and repair processes. Rejuran is now used in various clinical settings as part of skin treatment approaches.

The Science Behind Polynucleotides
Polynucleotides used in Rejuran are derived from salmon DNA, selected due to structural compatibility with human tissue. These molecules are processed into purified fragments that can interact with skin cells following administration.
When introduced into the skin, polynucleotides may support fibroblast activity and extracellular matrix function. This is associated with processes involved in collagen production, hydration, and skin structure.

Rejuran’s Role in Skin Treatment
Rejuran is used as part of treatment plans focused on skin quality. Its mechanism of action differs from volume-based injectables, as it is not designed to add structural volume but rather to support underlying skin processes.
Treatment approaches using Rejuran may be considered for areas such as:
Skin texture irregularities
Acne scarring
Redness
Pore appearance
Treatment suitability is assessed during consultation, and a personalised treatment plan is developed based on individual skin characteristics.

Rejuran in Clinical Practice
In South Korea, Rejuran is commonly used in protocols focused on gradual changes in skin quality. Multiple sessions are typically required, and outcomes vary between individuals.

Why Polynucleotides from Salmon Tissue
Polynucleotides derived from salmon tissue are used due to their compatibility with human skin and their role in biological processes related to tissue repair.

Research into polynucleotides suggests they may contribute to:
Cellular repair mechanisms
Inflammation modulation
Hydration-related processes within the skin
These properties form the basis for their use in clinical and aesthetic settings.

What to Expect During a Rejuran Treatment
At Beauty by Doctor (BBD) in Bondi Junction, Sydney, treatment protocols are individualised.
Preparation involves the application of a topical numbing agent to the treatment area.
Rejuran is administered via fine needle injections into targeted areas.
Following treatment, temporary redness and swelling may occur and generally resolve within 24 to 48 hours. Bruising may occur in some cases.
Recovery and response vary between individuals.

Rejuran in Aesthetic Medicine
Rejuran is one of several treatment options used in aesthetic medicine to address changes in skin quality over time. Its use is based on its interaction with cellular processes rather than structural alteration.

Why Choose Beauty by Doctor for Rejuran
Beauty by Doctor is a doctor-led clinic located in Sydney’s Eastern Suburbs. Treatments are performed following clinical assessment and are tailored to individual patient needs.

Dr Phoebe Jones has training in biostimulator techniques and oversees all treatment plans to ensure they are appropriate for each patient.
To learn more about Rejuran and whether it may be suitable for your concerns, consultation can be arranged either in clinic or via video.

Suitability for treatment is determined during consultation. All medical and cosmetic procedures carry risks, and outcomes vary between individuals. While complications are uncommon, it is important that potential risks, including rare adverse events, are understood. For more information, please refer to our Treatment Complications page: https://beautybydoctor.com/pages/concerns/treatment-complications